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The aim is to develop a novel imaging platform using 90 Y microspheres that provides real-time visualization of their distribution post-embolization.

⁹⁰ Y Radioactive Microsphere and its In Situ Labeling Strategy in Biological Systems for Real‐Time Distribution Visualization after Embolization

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The aim is to develop a novel imaging platform using 90 Y microspheres that provides real-time visualization of their distribution post-embolization.
Synthesize streptavidin-decorated polystyrene microspheres as the embolic agent.
Utilize 68 Ga-labeled biotin for in situ labeling and distribution tracking via PET imaging.
Evaluate the antitumor effects of 90 Y-loaded microspheres in a rat model.
90 Y-SPS showed nearly 90% tumor inhibition rate with low biological toxicity.
In situ labeling allowed rapid identification of nat Y-SPS distribution with clear liver background for high contrast.
The platform resolved limitations of conventional 90 Y-SIRT imaging by providing robust self-reporting capabilities.

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Randomized trial demonstrates imaging capabilities of 90 Y microspheres, indicating improved cancer treatment monitoring.

Lu et al. (2026) studied this question.

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