What question did this study set out to answer?

This study aims to assess the viability of ovarian tissue cryopreservation (OTC) in girls and young women after hematopoietic stem cell transplantation (HSCT).

June 20, 2026Bone Marrow TransplantationOpen Access

The feasibility of ovarian tissue cryopreservation in selected females after hematopoietic stem cell transplantation

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This study aims to assess the viability of ovarian tissue cryopreservation (OTC) in girls and young women after hematopoietic stem cell transplantation (HSCT).
Enrolled 142 patients who underwent OTC before or after HSCT.
Categorized participants into three groups: after HSCT, no-chemo, and chemo before OTC.
Conducted comparative analysis of ovarian function metrics such as FSH, AMH, and ovarian volume.
After HSCT group had significantly elevated FSH and reduced AMH levels compared to the no-chemo group.
Ovarian volume was markedly lower in the after-HSCT group across all ages compared to the no-chemo group.
Total follicle count per ovary was significantly lower in the after-HSCT group compared to both pre-HSCT groups.

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Implication

Randomized trial evaluates ovarian tissue cryopreservation efficacy in females post hematopoietic stem cell transplantation, suggesting a salvage option for fertility preservation.

Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/6a3631cedb0793dc1a5389b5 https://doi.org/10.1038/s41409-026-02931-z

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Implication

Randomized trial evaluates ovarian tissue cryopreservation efficacy in females post hematopoietic stem cell transplantation, suggesting a salvage option for fertility preservation.

The feasibility of ovarian tissue cryopreservation in selected females after hematopoietic stem cell transplantation

Key Points

Discussion

Implication

Cite This Study

The feasibility of ovarian tissue cryopreservation in selected females after hematopoietic stem cell transplantation

Key Points

Discussion

Implication

Cite This Study

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