Prospective, Double‐Blind, Vehicle‐Controlled Assessment of Topical Bakuchiol on Photoaging in a Chinese Population

Background Aging skin is a universal complaint among diverse patient populations. It encompasses physiologic changes to the skin, such as skin laxity, dyspigmentation, fine lines, and wrinkles. However, different populations may show different signs of aged skin. For example, Asian skin in particular exhibits stronger dyspigmentation in comparison to Caucasian skin. There has been a growing interest in using bakuchiol as an alternative to retinoids in treating the appearance of aging skin. This study explores how topical bakuchiol can improve the appearance of aging skin in a Chinese population. Aims This study evaluates the effects of topical bakuchiol on markers of aging skin, such as wrinkle severity, dyspigmentation, radiance, and pore size. Patients/Methods In this 84‐day study, 73 participants were randomized to receive either topical bakuchiol or a placebo. Participants were evaluated at five visits: Baseline, Day 28, Day 56, and Day 84. Facial photography and analysis were performed. Clinical grading assessed wrinkle severity, hyperpigmentation, skin radiance, and pore appearance. Tolerability was assessed. Results There was a significant reduction in wrinkle severity, hyperpigmentation, pore size, and improved radiance in the Bakuchiol group compared to the vehicle group in a Chinese population of women and men at days 24, 52, and 84. Conclusion The use of topical bakuchiol improved the appearance of wrinkle severity, hyperpigmentation, skin radiance, and pore size in a Chinese population.