Bioretinoids from microalgae: Boosting retinol performance and tolerability

Objective Skin ageing, hyperpigmentation, and texture are common dermatological concerns. Retinoids, including retinol, are widely used for their efficacy in treating these conditions. However, their side effects, such as irritation, often limit their use. Bakuchiol, a plant‐derived retinoid alternative, has gained attention for its gentler profile, but its efficacy remains a subject of comparison with traditional retinoids. The aim of the present study was to evaluate the efficacy of a novel microalgae‐derived bioretinoid (MBR) in comparison to retinol and bakuchiol in promoting skin regeneration, reducing ageing signs, and addressing hyperpigmentation. Methods The effects of MBR were evaluated in vitro for cell proliferation, melanin production, and extracellular matrix modulation. Clinically, MBR was applied to assess improvements in skin texture, firmness, elasticity, and pigmentation compared with reference treatments. Results In vitro, MBR significantly outperformed both retinol and bakuchiol in cell proliferation, melanin reduction, and ECM modulation. In vivo, MBR improved skin texture, firmness, and pigmentation, showing results comparable to retinol. MBR also synergistically enhanced retinol's effects, improving hydration and reducing irritation. Conclusion MBR is a promising alternative to traditional retinoids, offering enhanced efficacy in skin regeneration and pigmentation control with a more favourable safety profile, especially when combined with retinol.