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June 20, 2026Journal of Cutaneous Pathology

Elevated NLRP1 and IL ‐1β Expression Supports Inflammasome Activation in SJS / TEN

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Authors

MKMerve KayaBCBurak CelikKKKübra Katipoğlu

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Overview

Retrospective study analyzes inflammasome activation in SJS/TEN, suggesting NLRP1 as a disease severity biomarker.

Key Points

  • This study aims to characterize the role of NLRP1-mediated inflammasome activation in SJS and TEN.
  • Retrospective analysis of skin biopsy samples from 22 SJS/TEN patients and 18 controls with normal skin.
  • Immunohistochemical staining for NLRP1 and IL-1β assessed using H-scores.
  • Recorded clinical features including suspected triggers, SCORTEN, and outcomes.
  • NLRP1 and IL-1β expression significantly elevated in SJS/TEN compared to controls (p < 0.05).
  • NLRP1 levels showed a strong positive correlation with SCORTEN (p < 0.001).
  • No significant differences were found in expression between survivors and non-survivors.

Cite This Study

Kaya et al. (2026) studied this question.

synapsesocial.com/papers/6a363224db0793dc1a538c4dhttps://doi.org/10.1111/cup.70166
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