Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 20, 2026Chemistry & Biodiversity

Novel Quinoline‐4‐ester Derivatives as Antifungal Agent: Synthesis, and In Silico Study

View Full Paper
Ask AI
Bookmark
Share

Authors

XZXi ZhangZWZ B WangYWYu Wei

Discussion

Loading...

Member takes

Overview

Novel derivatives inhibit fungal growth in phytopathogenic fungi, suggesting new antifungal candidates.

Key Points

  • The study aims to synthesize and evaluate the antifungal activity of new quinoline-4-ester derivatives.
  • Synthesis of 2,3-dimethyl-8-fluoro-6-tert-butylquinoline-4-ester derivatives (5a-5p) and characterization through NMR, IR, and HRMS.
  • In vitro antifungal testing against ten phytopathogenic fungi with tebufloquin as control.
  • Performing molecular docking, DFT calculations, and ADMET predictions to assess structural and electronic properties.
  • Compound 5g was characterized by single-crystal x-ray diffraction.
  • Compounds 5j, 5l, and 5o exhibited 88.9% inhibition against Magnaporthe oryzae at 50 ppm.
  • Structure–activity relationship analysis indicated that electron-withdrawing groups enhance antifungal activity.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a3632a0db0793dc1a5393d6https://doi.org/10.1002/cbdv.71435
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Design, Synthesis, and In Vitro Enzymatic Evaluation of Novel Flavone Derivatives as Dual COX-2/5-LOX Inhibitors Supported by Molecular Docking and ADMET Analysis2026
  2. 2SWISS-MODEL: homology modelling of protein structures and complexes2018 · 14,074 citations
  3. 3Synthesis and in vivo fungicidal activity of some new quinoline derivatives against rice blast2017 · 56 citations
  4. 4Structure‐Activity Relationship of 7‐Chloro‐4‐(Phenylselanyl) Quinoline: Novel Antinociceptive and Anti‐Inflammatory Effects in Mice2024 · 5 citations
  5. 5Quinoline, quinazoline and acridone alkaloids2007 · 468 citations