Demonstrates an improved guanine protecting group enhancing oligonucleotide synthesis efficiency, indicating practical applications.
(2,7-Di- tert -butyl-9-fluorenyl)methyloxycarbonyl (DBmoc) is established as a robust guanine protecting group that facilitates efficient and scalable production of GuNA[ t -Bu]-modified oligonucleotides.
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Shrestha et al. (2026) studied this question.
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