What question did this study set out to answer?

To analyze a rare case of spontaneous regression in a poorly differentiated colorectal carcinoma with deficient mismatch repair.

June 20, 2026Surgical Case ReportsOpen Access

Spontaneous Regression of Poorly Differentiated Carcinoma in the Transverse Colon with Deficient Mismatch Repair: A Case Report and Review

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Case report illustrates spontaneous regression of colorectal cancer, indicating potential immunological mechanisms.

To analyze a rare case of spontaneous regression in a poorly differentiated colorectal carcinoma with deficient mismatch repair.
Case report detailing the patient’s clinical history and tumor characteristics
Review of existing literature on spontaneous regression in colorectal cancer
The case reports a notable regression of the tumor without conventional treatment
Immunological factors, especially related to dMMR and microsatellite instability, were suggested to influence regression

Takeyama et al. (2026) studied this question.

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