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August 22, 2026Journal of Digestive Cancer ResearchOpen Access

Regression-like Disappearance of Microsatellite-stable Rectal Adenocarcinoma before Surgery: A Case Report

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Authors

JHJeong Hee HanPusan National University HospitalBLByoung Chul LeePusan National University HospitalJCJung Bum ChoiPusan National University Hospital

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Implication

Case report demonstrates complete disappearance of rectal adenocarcinoma in a patient with microsatellite-stable disease, suggesting spontaneous regression occurs without high instability.

Key Points

  • To document a rare case of spontaneous regression-like clearance of biopsy-confirmed microsatellite-stable rectal adenocarcinoma prior to surgical resection.
  • Evaluated a 76-year-old female with biopsy-proven rectal adenocarcinoma using colonoscopy, abdominopelvic CT staging, and PCR-based microsatellite instability testing.
  • Performed robot-assisted low anterior resection approximately one month after diagnosis, followed by histopathologic evaluation of resected tissue and 10 regional lymph nodes.
  • Intraoperative colonoscopy and final histopathologic examination of the resected specimen revealed no residual carcinoma and zero metastases across 10 regional lymph nodes.
  • Polymerase chain reaction analysis of the initial diagnostic biopsy confirmed microsatellite-stable (MSS) tumor status.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/6a895f2aca7ade938187da9ahttps://doi.org/10.52927/jdcr.2026.14.2.185
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