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June 20, 2026Food & Function

Cinnamaldehyde, a major bioactive component of cinnamon bark, enhances social approach behavior associated with a liver–brain FGF21–isotocin axis in zebrafish

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Authors

YNYukiko NishiMKMomoko KawabeSMSeiwa Michihara

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Overview

Randomized trial examines how cinnamaldehyde affects social behavior in zebrafish, indicating potential biological mechanisms.

Key Points

  • This research investigates how cinnamaldehyde influences social approach behaviors and the underlying mechanisms involving the liver-brain FGF21-isotocin axis.
  • Analyzed the effects of cinnamaldehyde on zebrafish social behavior
  • Examined the role of FGF21 and isotocin in mediating these effects
  • Utilized multiple experimental setups for comprehensive assessment
  • Cinnamaldehyde significantly increased social approach behavior in zebrafish
  • Enhanced interaction was correlated with activated FGF21 and isotocin pathways
  • Behavioral changes suggest a novel liver-brain communication mechanism underlying social behaviors.

Cite This Study

Nishi et al. (2026) studied this question.

synapsesocial.com/papers/6a3632fcdb0793dc1a539622https://doi.org/10.1039/d6fo00815a
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advances in pharmacological effects and mechanism of action of cinnamaldehyde2024 · 50 citations
  2. 2Therapeutic uses of cinnamon (Cinnamomum verum) in human health: A review2025 · 1 citations
  3. 3Pharmacological Benefits of Cinnamaldehyde: A Comprehensive Insight2024
  4. 4Effect of Cinnamaldehyde Chalcone on Behavior in Adult <i>Zebrafish</i> (Danio rerio): <i>In Silico</i> Approach2024
  5. 5TO SYNTHESIZED AND EVALUATE CINNAMYL SCHIFF BASE FROM CINNAMALDEHYDE2026