Cinnamaldehyde, a major bioactive component of cinnamon bark, enhances social approach behavior associated with a liver–brain FGF21–isotocin axis in zebrafish

Yukiko Nishi; Momoko Kawabe; Seiwa Michihara; Shigeki Chiba; Yuko Kamada-Futagami; Toshiki Hyodo; Akio Inui; Kazuhiro Shiozaki

doi:10.1039/d6fo00815a

January 1, 2026Food & Function

Cinnamaldehyde, a major bioactive component of cinnamon bark, enhances social approach behavior associated with a liver–brain FGF21–isotocin axis in zebrafish

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Key Points

This research investigates how cinnamaldehyde influences social approach behaviors and the underlying mechanisms involving the liver-brain FGF21-isotocin axis.
Analyzed the effects of cinnamaldehyde on zebrafish social behavior
Examined the role of FGF21 and isotocin in mediating these effects
Utilized multiple experimental setups for comprehensive assessment
Cinnamaldehyde significantly increased social approach behavior in zebrafish
Enhanced interaction was correlated with activated FGF21 and isotocin pathways
Behavioral changes suggest a novel liver-brain communication mechanism underlying social behaviors.

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Implication

Examines how cinnamaldehyde affects social behavior in zebrafish, indicating potential biological mechanisms.

Abstract

Cinnamaldehyde is a major bioactive component of cinnamon bark and is widely consumed as a food-derived compound. However, its effects on social behavior and the underlying regulatory mechanisms remain poorly...

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Nishi et al. (2026) studied this question.

synapsesocial.com/papers/6a3632fcdb0793dc1a539622 https://doi.org/10.1039/d6fo00815a

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Cinnamaldehyde, a major bioactive component of cinnamon bark, enhances social approach behavior associated with a liver–brain FGF21–isotocin axis in zebrafish

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Cinnamaldehyde, a major bioactive component of cinnamon bark, enhances social approach behavior associated with a liver–brain FGF21–isotocin axis in zebrafish

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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