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June 20, 2026Open Access

Biomimetic 3D-printed gyroid scaffolds with versatile bioactive coatings for complex craniomaxillofacial bone regeneration

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Authors

CTCéline TourbierVBValentina BasoliMMMichaela Maintz

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Overview

Randomized trial develops a 3D-printed gyroid scaffold for bone regeneration, suggesting advancements in reconstructive surgery.

Key Points

  • To design a 3D-printed gyroid scaffold that enhances structural integrity and bioactivity for craniomaxillofacial bone regeneration.
  • Fabrication of a gyroid scaffold using poly(L-lactide-co-D,L-lactide) and β-tricalcium phosphate.
  • Mechanical testing to optimize wall thickness and porosity for compressive strength and elastic modulus.
  • Biofunctionalization with polydopamine and nano-hydroxyapatite to promote specific cellular responses.
  • Modulated wall thickness and porosity improved compressive strength and elastic modulus under physiological loads.
  • Biocompatibility confirmed through chemical and cytotoxicity analyses during manufacturing and sterilization processes.
  • Polydopamine suppressed mineralization in osteosarcoma cells, while polydopamine-nano-hydroxyapatite enhanced osteogenic differentiation and fibroblast adhesion.

Cite This Study

Tourbier et al. (2026) studied this question.

synapsesocial.com/papers/6a3632fcdb0793dc1a539740https://doi.org/10.26041/fhnw-16441
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