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June 20, 2026Annual Review of Virology

Viral Pleomorphism: How Virion Structure Guides Infection and Adaptation

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Authors

EPEdward A. PartlowCDCallie J. DonahueBMBalindile B. Motsa

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Overview

Review highlights the dynamic nature of virion shapes in infection environments, suggesting implications for viral persistence and fitness.

Key Points

  • The research aims to explore the variability of virion shapes and their impact on viral infection and evolution.
  • Reviewed foundational and recent studies on influenza virus pleomorphism over eight decades
  • Analyzed the structural and functional characteristics of viruses across various scales
  • Discussed technological advances in viral analysis and high-resolution measurements
  • Pleomorphism is shown to enhance viral fitness by adapting to infection environments
  • Virion shape varies significantly according to the infection context, challenging the notion of fixed viral characteristics
  • Emerging technologies are expected to address unanswered questions about viral pleomorphism biology

Cite This Study

Partlow et al. (2026) studied this question.

synapsesocial.com/papers/6a363326db0793dc1a539897https://doi.org/10.1146/annurev-virology-100424-110713
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