This review highlights the distinct structure and functional relevance of filamentous influenza virions, which are often overlooked due to laboratory adaptation.
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Filamentous virions in clinical influenza isolates may alter pathogenesis models; leaves open their role in human transmission and disease.
Clinical isolates of influenza virus produce pleomorphic virus particles, including extremely long filamentous virions. In contrast, strains of influenza that have adapted to laboratory growth typically produce only spherical virions. As a result, the filamentous phenotype has been overlooked in most influenza virus research. Recent advances in imaging and improved animal models have highlighted the distinct structure and functional relevance of filamentous virions. In this review we summarize what is currently known about these strikingly elongated virus particles and discuss their possible roles in clinical infections.
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Dadonaite et al. (2016) studied this question.
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