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June 21, 2026International Journal of General MedicineOpen Access

Regulatory T Cells Along the Pancreatitis–Pancreatic Cancer Continuum: Context-Dependent Immune Control and Therapeutic Opportunities

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Authors

HLHongmei LiPWPingping WangHCHongsuo Chen

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Overview

Review reveals regulatory T cell roles in pancreatitis and cancer, suggesting novel therapeutic strategies.

Key Points

  • This review aims to understand the context-dependent roles of regulatory T cells in pancreatic diseases, focusing on their dual roles in immune regulation and promotion of cancer.
  • Summarised mechanistic insights into Treg roles in acute and chronic pancreatitis and pancreatic ductal adenocarcinoma.
  • Analyzed Treg heterogeneity, tissue residency, and stage-specific functions.
  • Discussed therapeutic strategies that target Tregs directly or indirectly.
  • Tregs show protective functions in acute pancreatitis but can foster immune escape in pancreatic ductal adenocarcinoma.
  • Indiscriminate Treg depletion may worsen pancreatic tumorigenesis in certain contexts.
  • Proposed a translational framework for aligning Treg-targeted therapies with disease stages.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a377edf24f042ddf4c59bfahttps://doi.org/10.2147/ijgm.s611299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of T Regulatory Cell Infiltration on Survival Outcomes in Metastatic Pancreatic Cancer Patients with a Review of Immunobiology, Prognostic Value and Future Therapeutic Options2025
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  3. 3Targeting the dynamic transcriptional landscape of Treg subpopulations in pancreatic ductal adenocarcinoma: Insights from single-cell RNA sequencing analysis with a focus on CTLA4 and TIGIT2024 · 1 citations
  4. 4Abstract A085: Elucidating the Crosstalk between Cancer Associated Fibroblasts and the T Regulatory/T Helper 2 Axis in Pancreas Cancer2025
  5. 5Targeting Regulatory T Cells for Cancer Immunotherapy: Promises and Pitfalls.2026 · 1 citations