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November 30, 2025Journal of Clinical MedicineOpen Access

The Effect of T Regulatory Cell Infiltration on Survival Outcomes in Metastatic Pancreatic Cancer Patients with a Review of Immunobiology, Prognostic Value and Future Therapeutic Options

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Authors

DSDerya Kıvrak Salim CSCanan Sadullahoglu DSDerya Kıvrak Salim

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Implication

Retrospective analysis shows regulatory T cells impact survival outcomes in metastatic pancreatic cancer, suggesting therapeutic options may enhance immunotherapy response.

Key Points

Infiltration of T regulatory cells showed no significant prognostic effect on survival outcomes in pancreatic cancer patients.
High abundance of CD4+ and CD8+ T cells correlated with improved overall survival and progression-free survival.
Retrospective study utilized immunohistochemical profiling of 62 metastatic pancreatic cancer patients to evaluate immune cell subsets.
Findings suggest need for a deeper understanding of T regulatory cell roles in immunosuppression and therapeutic strategies.

Cite This Study

Salim et al. (2025) studied this question.

synapsesocial.com/papers/692b943e1d383f2b2a378913 https://doi.org/10.3390/jcm14238394

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Implication

Retrospective analysis shows regulatory T cells impact survival outcomes in metastatic pancreatic cancer, suggesting therapeutic options may enhance immunotherapy response.

The Effect of T Regulatory Cell Infiltration on Survival Outcomes in Metastatic Pancreatic Cancer Patients with a Review of Immunobiology, Prognostic Value and Future Therapeutic Options

Discussion

Member takes

Implication

Key Points

Cite This Study

The Effect of T Regulatory Cell Infiltration on Survival Outcomes in Metastatic Pancreatic Cancer Patients with a Review of Immunobiology, Prognostic Value and Future Therapeutic Options

Discussion

Member takes

Implication

Key Points

Cite This Study

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