Determination of the Effective Dose of Quercetin in Iron Overload Rabbits

The current study aimed to assess the effective dose of quercetin against iron overload in the adult rabbits by studying the dose response curve through using five successive doses of quercetin on serum iron and total iron binding capacity (TIBC) in iron overload rabbits. Thirty-six of adult male rabbits were used in current study and randomly divided in to the six groups and handled as follows for 28 and 42 days: Control group: rabbits were intraperitoneally (IP) injected with normal saline every 72 hours + normal saline orally each day while rabbits in the T1, T2, T3, T4 and T5 groups were administrated orally quercetin at doses 100,200,300,400 and 500 mg/kg B.W daily respectively and all animal were IP injected with iron dextran at dose of 100 mg/kg every 72 hours. Blood samples were collected after 28 and 42 days from ear vein. The results showed a significant increasing in serum iron of T1 and T2 groups, while T3, T4, and T5 groups not showed any significant difference when compared with control group, while TIBC in T4 and T5 not showed any significant difference when compared with control group after 28 and 42 days of quercetin treatment. Conclusion: As a results, obtained after 28 days of the experiment was used to calculate the ED of quercetin on iron overload which is 350 mg/kg.