Randomized trial shows improved sperm parameters and gene regulation in heat-stressed rabbits using PRP.
Autologous Platelet-Rich Plasma (PRP) has a potential effect on tissue repair through the proliferation and differentiation of tissue progenitor cells and is considered simple, safe, easy to prepare and use, easily applicable, and effective in use. Twenty New Zealand White rabbit were used and divided into two groups control (n=10), and the PRP group (n=10) which intratesticular injected with PRP (200 μl PRP per testes). In summer season, all animals were daily exposed to sunlight in the middle of the day for ten weeks of June, July, and August. The rectal temperature and temperature humidity index were obtained twice every week after exposure. The sperm parameters and gene expression of the target gene were analyzed before treatment and after 10 weeks. The Computer Assisted Semen Analysis (CASA) results showed that the sperm motility parameters were significantly (P<0.05) better for the summer heat-stressed in bucks injected with PRP than the control group. On the other hand, the gene expression of specific genes responsible for sperm motility (CFAP65 and SPEF2) results were noted that a high significant regulation (p<0.05) in the PRP group compared with the control. In conclusion, the PRP enhances the sperm parameters of rabbits that suffer from heat stress, as well as increases the regulation of CFAP65 and SPEF2 genes.
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Abdulla et al. (2023) studied this question.
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