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June 21, 2026International Journal of Molecular Medicine

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

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Authors

DADimitrios AndreikosMAMichael AschnerDZD. Ziogas

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Overview

Review highlights arsenic's role in skin cancer development, emphasizing public health strategies for exposed populations.

Key Points

  • This review examines the mechanisms linking arsenic exposure to skin cancer and the implications for public health.
  • Review of clinical evidence from endemic regions and occupational cohorts regarding arsenic exposure and skin cancer.
  • Analysis of molecular mechanisms involved in arsenic-associated skin carcinogenesis.
  • Discussion of the need for public health strategies and regulatory frameworks to reduce arsenic exposure.
  • Arsenic is established as a carcinogen, particularly in non-melanoma skin cancer (NMSC), with dose-responsive associations observed.
  • Evidence suggests some risk elevation for melanoma, although findings are inconsistent due to confounding factors.
  • Converging data from experimental and epidemiological studies affirm arsenic's role as an independent carcinogen for skin cancer.

Cite This Study

Andreikos et al. (2026) studied this question.

synapsesocial.com/papers/6a377edf24f042ddf4c59c2chttps://doi.org/10.3892/ijmm.2026.5893
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deficient arsenic methylation and global proteomic reprogramming in human keratinocytes during arsenic-induced skin carcinogenesis2026
  2. 2Toxicology of Airborne Inorganic Arsenic: Oxidative Stress, Molecular Mechanisms, and Organ-Specific Pathologies2025
  3. 3Rise in arsenic pollution and oral cancer: A call for action2024 · 5 citations
  4. 4Abstract 1473: Exposure of arsenic promotes malignant stemness and induces bladder malignancy in preclinical models2024
  5. 5Molecular Profiling and the Interaction of Somatic Mutations with Transcriptomic Profiles in Non-Melanoma Skin Cancer (NMSC) in a Population Exposed to Arsenic2024 · 6 citations