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June 21, 2026Physics in Medicine and BiologyOpen Access

Thermal and imaging effects of Feraheme in MR-guided focused ultrasound: a phantom study

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Authors

MIMyung‐Ho InZLZaiyang LongJHJ Hankiewicz

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Overview

Phantom study evaluates Feraheme as a contrast agent in MRgFUS, suggesting improved visualization and thermometry outcomes.

Key Points

  • This study aims to assess the impact of Feraheme on MR imaging, thermometry, and thermal response in tissue-mimicking phantoms used in MR-guided focused ultrasound.
  • Tissue-mimicking phantoms with varying Feraheme concentrations were created to measure effects on MR imaging and thermometry.
  • MR imaging was conducted at 1.5 T to evaluate signal-to-noise ratio and relaxation rates; acoustic attenuation was measured with ultrasound.
  • NMR spectroscopy assessed PRF coefficients at 3.0 T across Feraheme concentrations, repeated over three experiments in eight weeks.
  • At 0.25 mM Feraheme, GRE-based thermometry SNR increased by 12.6%, while at 0.5 mM it decreased by 27.1%.
  • Sonications in Feraheme phantoms produced statistically significant higher temperature elevations (p<0.001).
  • NMR measurements confirmed stable linear PRF temperature dependence and small predictable thermometry bias.

Cite This Study

In et al. (2026) studied this question.

synapsesocial.com/papers/6a377fb224f042ddf4c59fcbhttps://doi.org/10.1088/1361-6560/ae7f67
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