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June 21, 2026Journal of Chromatography BOpen Access

A method for quantifying non-esterified cis-9,trans-11-conjugated linoleic acid in finger-prick plasma by LC/ESI-MS/MS with isotope-coded derivatization

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Authors

KMKodai MaedaHIHayato IchimuraSOShoujiro Ogawa

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Overview

Randomized trial quantifies non-esterified cis-9,trans-11-CLA in plasma, indicating significant health benefits.

Key Points

  • To develop a sensitive method for quantifying non-esterified cis-9,trans-11-conjugated linoleic acid in finger-prick plasma.
  • Developed a liquid chromatography/electrospray ionization-tandem mass spectrometry method with isotope-coded derivatization.
  • Utilized DEMECAL device for minimally invasive blood collection and rapid plasma preparation.
  • Achieved high precision and accuracy with DAPTAD for isomer separation.
  • Limit of detection was 210 amol, higher sensitivity than any existing methods.
  • Relative standard deviations in five measurements ≤ 6.1%, demonstrating high precision.
  • Analytical recovery rates were 99.4–103.7%, confirming accuracy in real sample analysis.

Cite This Study

Maeda et al. (2026) studied this question.

synapsesocial.com/papers/6a377fb224f042ddf4c59ff1https://doi.org/10.1016/j.jchromb.2026.125194
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of dietary conjugated linoleic acid (CLA) on metabolism of isotope‐labeled oleic, linoleic, and CLA isomers in women2002 · 16 citations
  2. 2Effects of Linoleic Acid and Its Trans-10 Biohydrogenation Intermediates (Trans-10,Cis-12 Conjugated Linoleic Acid and Trans-10 18:1) on Lipogenic Gene Expression and Δ9-Desaturation Indices in Bovine Intramuscular Adipocytes2026
  3. 3Capillary electrophoresis quadrupole time-of-flight system metabolomic analysis revealed early onset metabolic change in adipose tissue of mice fed conjugated linoleic acid2026
  4. 4Supplementation with a 9c,11t‐rich conjugated linoleic acid blend shows no clear inhibitory effects on platelet function in healthy subjects at low and moderate cardiovascular risk: A randomized controlled trial2015 · 11 citations
  5. 5A UPLC-MS/MS method for simultaneous determination of arachidonic acid, stearic acid, and related endocannabinoids in human plasma2024 · 5 citations