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August 1, 2002Lipids

Effect of dietary conjugated linoleic acid (CLA) on metabolism of isotope‐labeled oleic, linoleic, and CLA isomers in women

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Authors

EEE. A. EmkenRAR. O. AdlofSDSandra M. Duval

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Overview

Controlled feeding trial reveals distinct isomer absorption and low metabolite conversion in women, indicating limited metabolic impact from supplementation.

Key Points

  • To evaluate the effect of dietary conjugated linoleic acid (CLA) supplementation on the accumulation and downstream metabolism of isotope-labeled oleic, linoleic, and CLA isomers.
  • Six healthy adult women consumed normal diets supplemented with either 6 g/d of sunflower oil or 3.9 g/d of CLA for 63 days.
  • Participants received an oral dose of deuterium-labeled fatty acid ethyl esters (10t,12c-18:2-d4, 9c,11t-18:2-d6, 9c-18:1-d8, and 9c,12c-18:2-d2).
  • Nine blood samples were collected over 48 hours to assess plasma lipid incorporation, absorption, and conversion into elongated or desaturated metabolites.
  • Dietary CLA supplementation showed no effect on the overall metabolism or incorporation rates of the deuterium-labeled fatty acids.
  • CLA isomers were absorbed 20% to 25% less effectively than oleic and linoleic acids, with 10t,12c-18:2 showing fourfold higher incorporation into 1-acyl PC and 9c,11t-18:2 showing two- to threefold higher incorporation into cholesterol esters.
  • Metabolic conversion was low, with the elongated metabolite 6c,10t,12c-18:3-d4 reaching only 6.8% of parental 10t,12c-18:2-d4 within plasma triglycerides, the only fraction with quantifiable levels.

Cite This Study

Emken et al. (2002) studied this question.

synapsesocial.com/papers/6a99e7dd8548cd35f93fd53ehttps://doi.org/10.1007/s11745-002-0956-5
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