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June 21, 2026Revista Sangre (ENG)Open Access

Large B-cell lymphoma: recommendations for next-generation sequencing

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Authors

CMCarolina Martínez‐LapercheHospital General Universitario Gregorio MarañónMAMiguel Alcoceba-SánchezSBSilvia Beà-Bobet

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Implication

Consensus guidelines recommend priority genetic alterations for next-generation sequencing in large B-cell lymphoma, enhancing diagnostics.

Key Points

  • To develop a consensus guideline for priority genes and alterations to assess by NGS in large B-cell lymphoma.
  • Collaborative review of literature and classifications by the Molecular Biology Group in Hematology and expert panel.
  • Selection and categorization of genes and chromosomal regions based on evidence levels (mandatory, recommended, optional).
  • Development of practical recommendations for implementation in clinical practice.
  • Agreement on 60 genes and several structural alterations relevant to large B-cell lymphoma.
  • Detailed genomic associations with molecular subtypes and their clinical implications outlined.
  • Guidelines aim to standardize diagnostic practices and enhance patient management.

Cite This Study

Martínez‐Laperche et al. (2026) studied this question.

synapsesocial.com/papers/6a377fb224f042ddf4c5a095https://doi.org/10.24875/sangree.m26000058
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic lymphocytic leukemia: recommendations for next-generation sequencing2026
  2. 2Mantle cell lymphoma: recommendations for next-generation sequencing2026
  3. 3Acute myeloid leukemia: recommendations for next-generation sequencing2026
  4. 4Myeloproliferative neoplasms: recommendations for next-generation sequencing2026
  5. 5High-risk subgroup and associated genes identified by next generation sequencing in diffuse large B cell lymphoma2026