Abstract Echo-planar imaging (EPI), commonly employed in functional MRI (fMRI), is highly susceptible to magnetic field inhomogeneities, leading to pronounced geometric distortions in reconstructed images. These distortions can result in substantial structural discrepancies between EPI and anatomical images acquired using the magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) method, thereby making it challenging to achieve accurate co-registration and subsequent localization of functional mapping. This issue can be effectively addressed by employing an anatomical imaging sequence that exhibits distortion profiles identical to those in EPI, referred to here as MP2EPI (magnetization-prepared 2 EPI). While this approach enables effortless co-registration with functional scans, it also introduces geometric distortions into the anatomical reference imaging, which limits its utility for analyses that rely on morphometric measurements or atlas-based segmentation. Distortion in MP2EPI can be corrected using additional data acquired with the reversed phase-encoding (PE) direction, which, however, significantly increases total acquisition time. To overcome this limitation, this work presents a novel MP2EPI sequence that simultaneously acquires reversed PE data within a single MP2EPI acquisition, without increasing the overall scan time. The primary focus of the current work is the technical implementation and validation of this sequence in the context of submillimeter fMRI at 7T.
Yun et al. (Fri,) studied this question.