What question did this study set out to answer?

This study aims to explore the role of psychiatric disorders and genetic risk in suicidal behaviors, distinguishing impacts in those with and without prior psychiatric issues.

June 21, 2026Acta Psychiatrica ScandinavicaOpen Access

Leveraging Family Genetic Risk Scores to Understand the Etiology of Suicidal Behaviors and Their Associations With Psychiatric Disorders

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Authors

SLSéverine LannoyVirginia Commonwealth University HOHenrik OhlssonSkåne University Hospital MSMallory StephensonVirginia Commonwealth University

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Implication

Randomized trial examines the links between genetic risk scores and suicidal behaviors in individuals, suggesting new screening needs.

Key Points

This study aims to explore the role of psychiatric disorders and genetic risk in suicidal behaviors, distinguishing impacts in those with and without prior psychiatric issues.
Analyzed data from 926,040 individuals born between 1980–1990 from Swedish national registries.
Evaluated family genetic risk scores for suicide attempts and deaths across individuals with and without psychiatric disorders.
Utilized Cox proportional hazards models to assess the influence of psychiatric disorders on the risk of suicidal behaviors.
Approximately 30% of individuals who attempted or completed suicide had a prior psychiatric diagnosis.
Family genetic risk scores for suicide attempts and deaths were higher in individuals with psychiatric disorders.
All psychiatric comorbidities significantly increased the risk of suicide attempts (HRs 4.61–9.03) and deaths (HRs 8.06–15.90).

Cite This Study

Lannoy et al. (2026) studied this question.

synapsesocial.com/papers/6a3780d724f042ddf4c5ae6b https://doi.org/10.1111/acps.70117

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Leveraging Family Genetic Risk Scores to Understand the Etiology of Suicidal Behaviors and Their Associations With Psychiatric Disorders

Discussion

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Implication

Key Points

Cite This Study

Leveraging Family Genetic Risk Scores to Understand the Etiology of Suicidal Behaviors and Their Associations With Psychiatric Disorders

Discussion

Member takes

Implication

Key Points

Cite This Study

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