What question did this study set out to answer?

The study aims to assess the structure of genetic risk factors for 18 psychiatric and substance use disorders using population-based registries.

Structure of the Genetic Risks for Psychiatric Disorders in Swedish Population-Based Registries

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Cohort study assesses genetic risks for multiple psychiatric disorders, revealing new insights about their structure.

The study aims to assess the structure of genetic risk factors for 18 psychiatric and substance use disorders using population-based registries.
Cohort study involving individuals born between 1960 and 2000 in Sweden.
Used family genetic risk scores calculated from first- through fifth-degree relatives.
Performed exploratory and confirmatory factor analyses on split-half samples of data.
Exploratory factor analysis identified a 6-factor structure for psychiatric disorders.
Mean interfactor correlation was 0.29, showing some relatedness among factors.
Findings included major depression loading on both mood and anxiety factors, with distinct interpretations for bipolar and schizoaffective disorders.

Kendler et al. (2026) studied this question.

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