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June 21, 2026International Journal of Molecular SciencesOpen Access

Evaluation of CXCL12 Diagnostic Performance in Tick-Borne Encephalitis and Other Central Nervous System Infections

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Authors

PSPaulina SwietonJSJakub SlonAMA. Moniuszko-Malinowska

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Overview

Randomized trial evaluates CXCL12 as a diagnostic marker in neuroinfections, suggesting potential for enhancing diagnostic accuracy.

Key Points

  • This research aims to evaluate the diagnostic performance of CXCL12 in identifying different neuroinfections, particularly tick-borne encephalitis.
  • Included 214 patients with confirmed meningitis and/or encephalitis, divided by etiology.
  • Measured CXCL12 levels and other inflammatory parameters in cerebrospinal fluid and serum.
  • Compared CXCL12 concentrations between neuroinfection patients and controls (N=25) and analyzed statistically.
  • CXCL12 concentrations were significantly higher in neuroinfection patients (AUC=0.791).
  • Better performance seen when CXCL12 combined with pleocytosis (AUC=0.761) to differentiate TBE from aseptic meningitis.
  • Utility in differentiating specific neuroinfection etiologies was limited, particularly in the purulent meningitis group.

Cite This Study

Swieton et al. (2026) studied this question.

synapsesocial.com/papers/6a3780d724f042ddf4c5aed0https://doi.org/10.3390/ijms27125549
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