Why the study?
The study was designed to assess the usefulness of cytokines and other soluble mediators to differentiate between severe and mild courses of tick-borne encephalitis and predict sequelae development.
Do CSF concentrations of cytokines and soluble mediators predict sequelae development in patients with tick-borne encephalitis?
Population
122 patients with tick-borne encephalitis
Comparison
Patients who developed sequelae vs patients with complete recovery
Authors
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CSF TRAIL/CCL20/MMP-8 elevations may flag TBE sequelae risk; leaves open clinical utility pending prospective validation.
Do CSF concentrations of cytokines and soluble mediators predict sequelae development in patients with tick-borne encephalitis?
Elevated CSF levels of TRAIL, CCL-20, and MMP-8 are promising biomarkers for predicting the development of sequelae in patients with tick-borne encephalitis.
Czupryna et al. (2024) studied this question.
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