What question did this study set out to answer?

This study aims to define the roles of ENO1 and PKM in HBV-associated HCC progression and viral replication.

ENO1 interacts with PKM to promote HBV-related hepatocellular carcinoma progression and HBV replication

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Randomized trial finds ENO1 and PKM interactions drive HBV-related HCC progression, suggesting new therapeutic targets.

This study aims to define the roles of ENO1 and PKM in HBV-associated HCC progression and viral replication.
Evaluated expression levels of ENO1 and PKM in HBV-infected HCC cells.
Performed co-immunoprecipitation to explore interactions between ENO1 and PKM.
Utilized an HCC mouse model to assess the impact of ENO1 and PKM on HCC progression and HBV replication.
ENO1 and PKM were significantly upregulated in HBV-associated HCC cells.
Co-IP assays demonstrated a direct interaction between ENO1 and PKM.
Higher levels of ENO1 and PKM led to increased HBV replication and accelerated HCC progression.

Hu et al. (2026) studied this question.

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