What question did this study set out to answer?

This study aims to investigate the role of ENO1 in the progression of HBV-associated hepatocellular carcinoma.

March 30, 2026Journal of Biochemical and Molecular Toxicology

HBx Promotes the Malignant Advancement of Hepatitis B Virus‐Associated Hepatocellular Carcinoma by Increasing ENO1 Expression

View Full Paper

Ask AI

Bookmark

Authors

HLHuan LiuShihezi University YHYan‐Chao Hu ZMZi‐Min Ma

Discussion

Member takes

Implication

Experimental findings demonstrate enolase-1's role in enhancing malignant behaviors of hepatocellular carcinoma, indicating its potential as an oncogene.

Key Points

This study aims to investigate the role of ENO1 in the progression of HBV-associated hepatocellular carcinoma.
Determined ENO1 expression using RT-qPCR, immunohistochemistry, and Western blot.
Conducted transfections for ENO1 and HBx overexpression or knockdown.
Evaluated cancer cell behavior using EdU staining, TUNEL staining, wound healing assay, and Transwell assay.
Assessed HBV replication by measuring HBV DNA, HBsAg, and HBV cccDNA levels.
Analyzed interaction of HBx with ENO1 using co-IP and Western blot analysis.
Elevated ENO1 expression was observed in HBV-associated hepatocellular carcinoma.
ENO1 overexpression enhanced proliferation, migration, invasion, and HBV replication while inhibiting apoptosis.
Silencing ENO1 led to opposite effects on malignant behavior.
HBx upregulated ENO1 expression and facilitated malignant advancement of HBV-HCC.
HBx silencing reduced malignant behaviors, countered by ENO1 overexpression.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69c9c553f8fdd13afe0bd3f1 https://doi.org/10.1002/jbt.70797

View Full Paper

Ask AI

Bookmark

Implication

Experimental findings demonstrate enolase-1's role in enhancing malignant behaviors of hepatocellular carcinoma, indicating its potential as an oncogene.

HBx Promotes the Malignant Advancement of Hepatitis B Virus‐Associated Hepatocellular Carcinoma by Increasing ENO1 Expression

Discussion

Member takes

Implication

Key Points

Cite This Study

HBx Promotes the Malignant Advancement of Hepatitis B Virus‐Associated Hepatocellular Carcinoma by Increasing ENO1 Expression

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider