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This case report aims to describe a rare instance of eosinophilic pneumonia induced by pomalidomide in a patient with multiple myeloma.

June 21, 2026BMC Pulmonary MedicineOpen Access

Pomalidomide-induced acute eosinophilic pneumonia: a case report

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This case report aims to describe a rare instance of eosinophilic pneumonia induced by pomalidomide in a patient with multiple myeloma.
Presented a case of a 67-year-old patient with relapsed multiple myeloma receiving pomalidomide, dexamethasone, and daratumumab.
Diagnosis confirmed through respiratory symptom assessment, imaging, bronchoalveolar lavage, and exclusion of alternative causes.
Intervention involved discontinuing pomalidomide and administering corticosteroids.
Eosinophilic pneumonia diagnosed post pomalidomide; rapid improvement noted after drug withdrawal.
Bronchoalveolar lavage showed eosinophilia, supporting the diagnosis.
Sustained pulmonary function recovery observed at 12-month follow-up.

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Case report reveals eosinophilic pneumonia in a patient on pomalidomide, highlighting the need for prompt recognition and intervention.

Megevet et al. (2026) studied this question.

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