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A41-01 Lenalidomide-Associated Acute Fibrinous and Granulomatous Pneumonitis Mimicking Miliary Infection

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To describe a rare case of lenalidomide-associated acute fibrinous and granulomatous pneumonitis.
Case presentation of a 44-year-old woman with multiple myeloma and acute respiratory symptoms post-transplant.
Diagnostic imaging and laboratory results confirmed eosinophilia, neutropenia, and pneumonia-like CT findings.
Treatment involved cessation of lenalidomide and steroids, with follow-up imaging to assess recovery.
CT imaging showed miliary patterns and ground-glass opacities, initially misdiagnosed as infection.
Positive BAL differential indicated eosinophilia and lymphocytic response, with all cultures being negative.
Symptomatic improvement occurred after withdrawal of lenalidomide, confirmed by follow-up imaging.

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Case report reveals lenalidomide-induced pneumonitis in a multiple myeloma patient, suggesting the need for awareness and prompt treatment.

Khattar et al. (2026) studied this question.

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Case report reveals lenalidomide-induced pneumonitis in a multiple myeloma patient, suggesting the need for awareness and prompt treatment.