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June 21, 2026Discover Public HealthOpen Access

Differential associations of serum 25-hydroxyvitamin D and calcium with trabecular and cortical bone mineral density in postmenopausal women assessed by peripheral quantitative computed tomography

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Authors

SMSD MishraVDVandana DhamaSSShakun Singh

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Overview

Cross-sectional study evaluates vitamin D and calcium impacts on bone density in postmenopausal women, suggesting targeted supplementation is needed.

Key Points

  • This study aims to clarify how serum 25-hydroxyvitamin D and calcium differentially affect trabecular and cortical bone mineral density in postmenopausal women.
  • Cross-sectional study involving 100 postmenopausal women aged 55–69 years
  • Measured serum 25(OH)D and calcium levels; assessed bone mineral density via pQCT
  • Employed Pearson correlation and multivariable linear regression analyses adjusted for age, BMI, and other factors.
  • Significant correlation of 25(OH)D with cortical BMD (r = 0.513, p < 0.001) but not with trabecular BMD (r = 0.027, p = 0.788)
  • Calcium shown to correlate with trabecular BMD (r = 0.534, p < 0.001) and, to a lesser extent, with cortical BMD (r = 0.231, p = 0.021)
  • Calcium and years since menopause independently predicted trabecular BMD, while age and calcium predicted cortical BMD.

Cite This Study

Mishra et al. (2026) studied this question.

synapsesocial.com/papers/6a37818f24f042ddf4c5b598https://doi.org/10.1186/s12982-026-02333-y
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