Key result
AMI shifts macrophage supply to blood monocytes, increasing systemic leucocytes and linking to CV mortality.
Why the study?
Blood leucocytosis closely associates with cardiovascular mortality, providing motivation to understand how and why organ ischaemia alters cellular immunity in ischaemic heart disease.
This review highlights how acute myocardial infarction alters innate immune cell pathways, increasing systemic leucocyte supply which is closely associated with cardiovascular mortality.
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Post-MI macrophage shift from resident to monocyte-derived may affect healing; leaves open targeted immunomodulation strategies.
Nahrendorf et al. (2015) conducted a review in Ischaemic heart disease and myocardial infarction. Innate immune cell pathways was evaluated. Acute myocardial infarction alters the macrophage phenotype and supply chain from tissue resident to blood monocytes, increasing systemic leucocyte supply and associating with cardiovascular mortality.
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