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June 22, 2026Biomedical AnalysisOpen Access

Progress in non-endocytic dependent transmembrane delivery of biological macromolecules

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Authors

MYMaosong YangAnhui University of Science and TechnologyJWJiheng WangAnhui University of Science and TechnologyCCChang Chen

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Implication

Review outlines recent non-endocytic methods for delivering biomacromolecules to cells, suggesting improved therapeutic applications.

Key Points

  • This review aims to explore non-endocytic strategies that improve the delivery of biomacromolecules across cell membranes.
  • Systematic overview of direct delivery mechanisms
  • Emphasis on physical membrane poration and cell-penetrating peptides
  • Evaluation of membrane fusion, phase-separated carriers, and biological machines
  • Enhanced delivery of biomacromolecules into the cytosol while avoiding endosomal degradation
  • Identification of innovative solutions for therapeutic delivery and cellular engineering
  • Highlighting approaches that increase intracellular bioavailability of therapeutic agents

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a38d0fdda1bad9caca30bddhttps://doi.org/10.1016/j.bioana.2026.05.003
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