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June 22, 2026ORL

Risk Factors for Intubation-Related Laryngeal Granulomas: A Prospective Study in Surgical Patients

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Authors

TWTakashi WadaMKMachiko KimuraYAYasuhiro Arai

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Overview

Prospective cohort study identifies intubation duration and tube type as key risk factors for laryngeal granulomas post-surgery, suggesting careful choice of equipment.

Key Points

  • This research investigates the frequency and risk factors of intubation-related laryngeal granulomas in surgical patients.
  • Single-center prospective cohort study conducted from November 2012 to September 2013
  • Patients underwent elective surgery requiring intubation for at least 5 hours
  • Evaluated associations using univariate tests and multivariable logistic regression.
  • ILGs detected in 25% of patients at 1 week post-extubation, particularly after cardiovascular surgeries.
  • Intubation duration ≥ 13 hours (aOR 10.697, 95% CI 1.639–69.828; p=0.013) and DLT use (aOR 14.521, 95% CI 1.531–137.680; p=0.020) were significant risk factors.
  • 80% of ILG cases resolved spontaneously within 1 month.

Cite This Study

Wada et al. (2026) studied this question.

synapsesocial.com/papers/6a38d152da1bad9caca3100dhttps://doi.org/10.1159/000553227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Laryngeal granulomas: A rare clinical entity requiring etiology-specific management – A retrospective study of 16 cases2025
  2. 2Consequences of NICU Intubations: Incidence, Identifications, and Interventions2024 · 2 citations
  3. 3Study of Endoscopic Characteristics of Laryngeal Lesions in Patients with Prolonged Endotracheal Intubation2026
  4. 4Post-extubation laryngitis in children: diagnosis, management and follow-up2024 · 1 citations
  5. 5Laryngeal Injuries Following General Endotracheal Anesthesia: A Case Series2026