Analysis of the effectiveness of the myocardial work index in the assessment of cancer therapy-related cardiac dysfunction

Objective: To investigate the correlation between myocardial global work index (GWI) and cancer therapyrelated cardiac dysfunction (CTRCD) during chemotherapy for patients with thoracic tumors.Methods: A retrospective analysis was conducted on 87 patients with thoracic tumors who underwent chemotherapy at The Third Hospital of Hebei Medical University from April 2022 to June 2023.Among them, 37 patients who developed CTRCD during chemotherapy were assigned to the research group, and the remaining 50 patients without CTRCD were assigned to the control group.Myocardial GWI was compared between the two groups at three time points: before chemotherapy (T0), during chemotherapy cycle 3 (T1), and upon completion of chemotherapy (T2).The predictive value of myocardial GWI at T0 and T1 for CTRCD was analyzed.Patients were followed up for prognosis, and the relationship between myocardial GWI at T2 and the recovery from CTRCD was evaluated.Additionally, the correlation between myocardial GWI and Creatine Kinase-MB (CK-MB) and cardiac troponin T (cTnT) at T0-T2 was analyzed.Results: The myocardial GWI in the research group was lower than that in the control group at T0-T2 (P < 0.05).Myocardial GWI at T0 and T1 showed excellent predictive accuracy for the occurrence of CTRCD.In addition, patients in the research group who recovered from CTRCD had a higher myocardial GWI at T2 compared to those who did not (P < 0.05).The myocardial GWI was negatively correlated with CK-MB and cTnT at T0-T2 (P < 0.05).Conclusion: Myocardial GWI is a reliable predictor for the occurrence of CTRCD during chemotherapy in patients with thoracic tumors, providing valuable clinical insights.