Key result
In an in silico model of chronic atrial fibrillation, IKur inhibitors with slow recovery kinetics effectively reduced the number of spiral waves from 5 to 1 or 3 by increasing the percent area of refractory tissue.
Why the study?
Do IKur inhibitors with specific kinetic properties reduce spiral wave activity in an in silico model of chronic atrial fibrillation?
Do IKur inhibitors with specific kinetic properties reduce spiral wave activity in an in silico model of chronic atrial fibrillation?
Absolute Event Rate: 1% vs 5%
In an in silico model of chronic atrial fibrillation, the antiarrhythmic efficacy of IKur inhibitors depends critically on their kinetic properties, specifically their ability to prolong the wavelength and increase the percent area of refractory tissue.
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Kinetic selectivity of IKur blockade may govern antiarrhythmic efficacy in AF models; leaves open whether this informs drug development or clinical testing.
Scholz et al. (2013) studied Chronic Atrial Fibrillation. IKur inhibitors with different kinetic properties vs. Control cAF conditions was evaluated on Number of spiral waves (rotors) after 30 seconds. In an in silico model of chronic atrial fibrillation, IKur inhibitors with slow recovery kinetics effectively reduced the number of spiral waves from 5 to 1 or 3 by increasing the percent area of refractory tissue.
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