Key result
Kir3.1 and Kir3.4 are abundant in the atrium and sinoatrial node of rats, guinea pigs, and ferrets, co-localizing with m2 muscarinic receptors, but have very low or undetectable abundance in the ventricle.
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Supports atrial IKACh targeting in preclinical models; leaves open human ventricular expression and clinical translation.
Dobrzynski et al. (2001) studied this question. Muscarinic K+ channel proteins Kir3.1 and Kir3.4 distribution was evaluated on Abundance and cellular location of Kir3.1 and Kir3.4. Kir3.1 and Kir3.4 are abundant in the atrium and sinoatrial node of rats, guinea pigs, and ferrets, co-localizing with m2 muscarinic receptors, but have very low or undetectable abundance in the ventricle.
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