Key result
The chronotropic effects of acetylcholine and vagal stimulation on the rabbit sinoatrial node are primarily mediated by the activation of the acetylcholine-activated potassium current (iK,ACh).
Population
Single cells, small multicellular preparations, and intact preparations from the rabbit sinoatrial node
Comparison
Bath applied acetylcholine and postganglionic… vs Control conditions without ion channel blockers
Design
Preclinical
Authors
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Acetylcholine slowing of rabbit SA node is not principally via i(f) or iCa suppression; challenges prior assumptions and leaves dominant mechanism open.
The chronotropic effects of acetylcholine and vagal stimulation on the rabbit sinoatrial node are primarily mediated by the activation of the acetylcholine-activated potassium current (iK,ACh) rather than suppression of i(f) or iCa.
Boyett et al. (1995) studied this question. Bath applied acetylcholine and vagal stimulation vs. Control conditions and specific ion channel blockers was evaluated on Chronotropic effect (rate of spontaneous action potentials). The chronotropic effects of acetylcholine and vagal stimulation on the rabbit sinoatrial node are primarily mediated by the activation of the acetylcholine-activated potassium current (iK,ACh).
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