Key result
Mathematical modeling of rabbit sinoatrial node cells showed that the negative chronotropic effect of acetylcholine is principally driven by activation of iK,ACh.
Mathematical modeling demonstrates that the negative chronotropic effect of acetylcholine on sinoatrial node cells is primarily driven by activation of iK,ACh rather than inhibition of iCa,L.
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Model identifies iK,ACh as dominant in ACh slowing; leaves open experimental validation in intact human SA node.
Zhang et al. (2002) studied this question. Acetylcholine was evaluated on 50% decrease in pacemaking rate. Mathematical modeling of rabbit sinoatrial node cells showed that the negative chronotropic effect of acetylcholine is principally driven by activation of iK,ACh.
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