Key result
Higher plasma renin activity levels were associated with a 43% increased risk of combined cardiovascular events among individuals with systolic blood pressure ≥140 mmHg.
Why the study?
Does higher plasma renin activity increase the risk of cardiovascular events and mortality in adults with elevated blood pressure?
Population
6,331 adults within an integrated health system, categorized by systolic blood pressure.
Comparison
Higher plasma renin activity tertiles vs Lowest plasma renin activity (PRA) tertile (T1)
Design
Cohort
Authors
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Higher PRA linked to CV events in hypertension; hypothesis-generating and requires prospective confirmation before guiding therapy.
Cohort (n=6,331)
Yes
Does higher plasma renin activity increase the risk of cardiovascular events and mortality in adults with elevated blood pressure?
Hazard Ratio: 1.43 (95% CI 1.1–1.86)
Higher plasma renin activity is associated with an increased risk of ischemic heart events and congestive heart failure in individuals with elevated systolic blood pressure (≥ 140 mmHg), but not in those with controlled blood pressure.
Bhandari et al. (2016) conducted a cohort in Elevated and nonelevated blood pressure (n=6,331). Elevated plasma renin activity (highest tertile) vs. Lowest plasma renin activity tertile was evaluated on Combined cardiovascular events in subjects with SBP ≥140 mmHg (HR 1.43, 95% CI 1.10-1.86). Higher plasma renin activity levels were associated with a 43% increased risk of combined cardiovascular events among individuals with systolic blood pressure ≥140 mmHg.
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