Background: Infertility can be defined as the inability to conceive pregnancy when sexually active and not having used any contraception in 12 months. Flaxseed oil has wide-spectrum applications in health. It has been receiving special interest in infertility treatment. Objectives: This research aimed to determine the impact of flaxseed oil on the fertility of mice. Methods: It involved seventy-five mice. These mice were sex-separated and randomly classified into three groups; one group served as a control group, and the other two groups were exposed to flaxseed oil extract at a dose of 60 mg/Kg body weight/day or 120 mg/Kg body weight/day for 2 weeks. The animals were redistributed at the end of the treatment period, whereby each female group was exposed to male mice from the three male groups for four weeks to investigate reproductive efficiency by calculating the pregnancy rate among females. In males, sperm count was performed with histopathological examination of the testes and epididymis. Results: No pregnancies occurred in the flaxseed oil-treated groups, and azoospermia was observed in all the treated male groups, with marked histological alterations in the testes and epididymis. Conclusion: Flaxseed oil had a negative influence on reproduction in both male and female mice in terms of pregnancy percentage, sperm count, with histological changes in the testis and epididymis.
Albadran et al. (Sat,) studied this question.