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Mini-review examines how stress affects prolactin levels and implications for hyperprolactinemia management.
The physiological functions of prolactin are highly varied, despite the fact that it is most commonly recognized for its participation in the inhibition of reproduction and the regulation of breastfeeding. The conditions known as hyperprolactinemia can have a variety of origins, some of which are physiological and others of which are pathologic. The following are examples of physiological causes: pregnancy, breastfeeding, sleep-related, stimulation of the nipples and sexual orgasm, stimulation or trauma to the chest wall. Another significant physiological factor that contributes to hyperprolactinemia is stress, and the clinical importance of this factor is currently being investigated. This paper aims to elucidate the physiology of prolactin, the influence of stress on its secretion, and the overarching clinical strategy for managing hyperprolactinemia.
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Mahdi et al. (2026) studied this question.
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