APOE-e4*4 increases Alzheimer’s disease risk by approximately 12- to 15-fold relative to APOE-e3*3 in the Japanese population, comparable to risk in Caucasian populations.
Does the APOE-e4*4 genotype increase the risk of Alzheimer's disease compared to APOE-e3*3 in the Japanese population?
The risk of Alzheimer's disease associated with the APOE-e4*4 genotype in the Japanese population is 12-15-fold higher than APOE-e3*3, which is comparable to Caucasian populations and lower than previously reported.
Absolute Event Rate: 0% vs 0%
Abstract Our meta-analysis demonstrates that the risk effect of APOE-e4*4 relative to APOE-e3*3 for Alzheimer’s disease in the Japanese population is approximately 12–15-fold, comparable to that reported in Caucasian populations, rather than greater than 20-fold as previously reported.
Miyashita et al. (Wed,) reported a other. APOE-e4*4 increases Alzheimer’s disease risk by approximately 12- to 15-fold relative to APOE-e3*3 in the Japanese population, comparable to risk in Caucasian populations.