Key result
Elevated TyG-WHtR linked to ~49% higher risk of decreased eGFR in elderly hypertensives, outperforming other indices.
Why the study?
Does elevated TyG-WHtR predict reduced eGFR in elderly hypertensive patients?
Cross-Sectional (n=3,764)
Yes
Does elevated TyG-WHtR predict reduced eGFR in elderly hypertensive patients?
Elevated TyG-WHtR is an independent risk factor and a superior predictor for reduced eGFR in elderly hypertensive patients compared to other TyG-related indices.
Answers are grounded in this paper and cite their sources.
TyG-WHtR may aid reduced eGFR risk stratification in elderly hypertensives; leaves open prospective validation and outcome impact.
Background The triglyceride-glucose index (TyG) and its derivatives, such as the TyG-waist-to-height ratio (TyG-WHtR), provide reliable surrogate measures for estimating insulin resistance (IR). Their associations with renal function in hypertensive patients remain unclear. This study examined the associations of TyG-WHtR and its related indices with estimated glomerular filtration rate (eGFR) in a community-based elderly hypertensive population. Methods This cross-sectional study assessed the clinical indicators, TyG-related indices, and eGFR in a cohort of 3,764 hypertensive adults aged ≥65 years from Huaian, China, employing restricted cubic spline models (RCS), logistic regression, spearman correlation, and receiver operating characteristic (ROC) curve analyses to evaluate the associations and predictive utility of TyG-WHtR and related parameters for identifying impaired renal function, defined by reduced eGFR. Results A total of 612 participants (16.25%) had reduced eGFR. Significant predictors of reduced eGFR included elevated TyG-WHtR and related indices, with TyG-WHtR showing a particularly robust association in both pre- and post-adjustment analyses. These indices correlated negatively with high-density lipoprotein cholesterol (HDL-C), and positively with measures of adiposity, fasting plasma glucose (FPG), and non-HDL cholesterol. Significant interactions were found for gender, age, and alcohol consumption. TyG-WHtR alone had an AUC of 0.596, but after adjustment its predictive ability improved to 0.864, demonstrating superior performance compared to TyG, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC). Conclusion Elevated TyG-WHtR is an independent risk factor for the decline in eGFR in elderly patients with hypertension, demonstrating superior predictive value compared to other TyG-related indices. TyG-WHtR may serve as a useful marker for early identification of renal dysfunction in this population.
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Ling et al. (2026) conducted a cross-sectional in Hypertension with reduced kidney function (n=3,764). Elevated TyG-WHtR (Triglyceride-glucose-waist-to-height ratio) vs. Lower TyG-WHtR or other TyG-related indices was evaluated on Decreased estimated glomerular filtration rate (eGFR) (OR 1.49, 95% CI 1.25-1.79, p=<0.001). Elevated TyG-WHtR was independently associated with a higher risk of decreased eGFR (OR 1.49) in elderly hypertensive patients, demonstrating superior predictive value compared to other TyG indices.
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