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March 4, 2025BMC Public HealthOpen Access

The association between derived TyG index and the risk of heart failure in the elderly population: a prospective cohort study from 2017 to 2023

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Why the study?

Although the triglyceride-glucose (TyG) index identifies insulin resistance, comprehensive evidence was lacking regarding whether integrating it with obesity indices enhances predictive capacity for heart failure.

Do derived TyG indices combined with obesity indices predict the risk of developing heart failure in older adults?

Population

7,335 adults aged 60 years and above

Comparison

TyG combined with obesity indices (TyG-BMI, TyG-WC, TyG-WHtR) and longitudinal trajectories

Design

Prospective cohort study

Follow-up

Average follow-up period of 2.97 years

Authors

XDXinyang DuiSichuan UniversityXCXin ChenSongjiang District Central HospitalLZLinlin ZhuJiangsu Provincial Meteorological Bureau

Discussion

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Implication

TyG-obesity composites were associated with HF risk; leaves open whether they improve prediction beyond established factors in clinical practice.

Structured PICO

Do derived TyG indices combined with obesity indices predict the risk of developing heart failure in older adults?

P
Population
7,335 older adults aged 60 years and above who completed at least twice periodical health examinations in the National Basic Public Health Service at the Hongguang Community Health Service Center
I
Intervention
Derived TyG indices combined with obesity indices (TyG-BMI, TyG-WC, TyG-WHtR) and their longitudinal trajectories
C
Comparator
Different levels and trajectories of TyG-derived indices
O
Outcome
Risk of developing heart failure (HF)hard clinical

Derived TyG indices combined with obesity indicators, as well as their longitudinal trajectories, can serve as effective biomarkers for identifying older adults at high risk of developing heart failure.

Cite This Study

Dui et al. (2025) studied this question.

synapsesocial.com/papers/6a87a488cc0e5f225b9751c5https://doi.org/10.1186/s12889-025-22046-2

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Triglyceride Glucose-Waist Circumference Better Predicts Coronary Calcium Progression Compared with Other Indices of Insulin Resistance: A Longitudinal Observational Study2020 · 88 citations
  2. 2Relationship of body mass index and waist circumference with clinical outcomes following percutaneous coronary intervention2018 · 20 citations
  3. 3Heart Failure in the Elderly2003 · 23 citations
  4. 4Prevalence estimates of the insulin resistance and associated prevalence of heart failure among United Status adults2023 · 30 citations
  5. 5Link between triglyceride-glucose-body mass index and future stroke risk in middle-aged and elderly chinese: a nationwide prospective cohort study2024 · 115 citations