83366 | Balloon-Expandable Valves Are Associated with Higher Prosthesis–Patient Mismatch in Medium and Large Annulus Transcatheter Aortic Valve Replacement

Q: What does this research mean for the field?

Balloon-expandable valves are associated with a higher incidence of prosthesis–patient mismatch in medium and large annulus transcatheter aortic valve replacement. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Omar Saleh; Rishab Agarwal; Israa Saleh; Deepak R. Talreja; Clinton Kemp; Benjamin Peterson; Matthew Summers

doi:10.1016/j.shj.2026.100997

June 1, 2026Structural HeartOpen Access

83366 | Balloon-Expandable Valves Are Associated with Higher Prosthesis–Patient Mismatch in Medium and Large Annulus Transcatheter Aortic Valve Replacement

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Key result

Balloon-expandable valves linked to higher PPM in medium and large annulus TAVR.

Why the study?

Are balloon-expandable valves associated with higher prosthesis-patient mismatch in medium and large annulus TAVR?

Key Points

To determine whether platform-related hemodynamic differences and prosthesis–patient mismatch persist across medium and large aortic annulus sizes following transcatheter aortic valve replacement.
Assessed post-procedural hemodynamics and prosthesis–patient mismatch across the spectrum of aortic annulus dimensions.
Compared outcomes between balloon-expandable transcatheter heart valve platforms and alternative valve designs.
Balloon-expandable valve platforms were associated with significantly higher rates of prosthesis–patient mismatch in both medium and large aortic annuli.
Hemodynamic disparities between transcatheter valve designs are not restricted to small annuli and extend across broader anatomical size ranges.

Structured PICO

Are balloon-expandable valves associated with higher prosthesis-patient mismatch in medium and large annulus TAVR?

P

Population

Patients undergoing transcatheter aortic valve replacement (TAVR) with medium and large annuli

I

Intervention

Balloon-expandable valves

O

Outcome

Prosthesis-patient mismatchsurrogate

Implication

Balloon-expandable valves may be associated with higher rates of prosthesis-patient mismatch even in patients with medium and large annuli undergoing TAVR.

Abstract

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Discussion

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Cite This Study

Saleh et al. (2026) studied this question. Balloon-expandable valves are associated with higher prosthesis-patient mismatch in medium and large annulus transcatheter aortic valve replacement.

synapsesocial.com/papers/6a3c237ed15afadd906fa398 https://doi.org/10.1016/j.shj.2026.100997

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83366 | Balloon-Expandable Valves Are Associated with Higher Prosthesis–Patient Mismatch in Medium and Large Annulus Transcatheter Aortic Valve Replacement

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

83366 | Balloon-Expandable Valves Are Associated with Higher Prosthesis–Patient Mismatch in Medium and Large Annulus Transcatheter Aortic Valve Replacement

Key Points

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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