Key result
Left atrial appendage closure compared to direct oral anticoagulation was evaluated in four randomized trials that were individually underpowered for key outcomes.
Meta-analysis evaluates stroke prevention outcomes of left atrial appendage closure versus direct oral anticoagulants in atrial fibrillation, highlighting evidence from pooled randomized trials.
Left atrial appendage closure (LAAC) has emerged as an alternative to direct oral anticoagulation (DOAC) for stroke prevention in atrial fibrillation (AF). Four RCTs (CHAMPION-AF, CLOSURE-AF, PRAGUE-17, and OPTION) compared LAAC with DOACs, but each was underpowered for key outcomes.
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Moyal et al. (2026) studied this question. Left atrial appendage closure compared to direct oral anticoagulation was evaluated in four randomized trials that were individually underpowered for key outcomes.
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