Key result
LAAC compares with oral anticoagulation for ischemic stroke, bleeding, and mortality in AF.
Meta-analysis evaluates left atrial appendage closure versus oral anticoagulation in atrial fibrillation, highlighting impacts on stroke, bleeding, and mortality.
To compare left atrial appendage closure (LAAC) with medical therapy in atrial fibrillation, focusing on ischemic stroke, bleeding, and mortality. Methods: We performed a meta-analysis of randomized trials comparing LAAC with oral anticoagulation or physician-directed medical therapy.
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Mohamed et al. (2026) studied this question. Left atrial appendage closure was compared with oral anticoagulation or medical therapy in a meta-analysis assessing ischemic stroke, bleeding, and mortality in atrial fibrillation.
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