Assessment of Systemic Immune-Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI) in Patients Undergoing Bariatric Surgery

Background: Obesity became an important health problem in last years. It’s relation with many inflammatory markers and indexes were studied. Aim: The present study aimed to analyze the role of Systemic Immune Inflammation Index (SII) and Systemic Inflammatory Response Index (SIRI) in bariatric surgery. Materials and Methods: Single-center, observational, cross-sectional, and retrospective study was carried out. Data about demographics, comorbidities, excess weight loss (EWL), as well as body mass index (BMI) , laboratory results, and inflammatory markers including platelet lymphocyte ratio (PLR), neutrophil lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR) were recorded preoperatively and postoperatively at 1st, 6th, 12th and 24th months. The SII and SIRI values also calculated preoperatively and at 1st, 6th, 12th and 24th months after surgery. Results :A total of 149 patients operated on by a single surgeon were studied. The mean age of the patients was 36.77±11.39 (18-66). When we compare the preoperative and postoperative values of SII and SIRI, all values were decreased after bariatric surgery. Conclusions: Inflammatory indexes, SII and SIRI were decreased after bariatric surgery. Although there was a weak correlation between EWL and SIRI only at the postoperative 24 months, there was no clear relationship in between EWL and SII/SIRI in all other time periods.